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Activation of LANCL2 by BT-11 Ameliorates IBD by Supporting Regulatory T Cell Stability Through Immunometabolic Mechanisms

BACKGROUND: Inflammatory bowel disease (IBD) afflicts 5 million people and is increasing in prevalence. There is an unmet clinical need for safer and effective treatments for IBD. The BT-11 is a small molecule oral therapeutic that ameliorates IBD by targeting lanthionine synthetase C-like 2 (LANCL2...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Inflamm Bowel Dis
Main Authors: Leber, Andrew, Hontecillas, Raquel, Zoccoli-Rodriguez, Victoria, Bassaganya-Riera, Josep
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6241665/
https://ncbi.nlm.nih.gov/pubmed/29718324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ibd/izy167
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