hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction

Telomeres protect against chromosomal damage. Accelerated telomere loss has been associated with premature aging syndromes such as Werner’s syndrome and Dyskeratosis Congenita, while, progressive telomere loss activates a DNA damage response leading to chromosomal instability, typically observed in...

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Veröffentlicht in:PLoS One
Hauptverfasser: Guha, Manti, Srinivasan, Satish, Johnson, F. Bradley, Ruthel, Gordon, Guja, Kip, Garcia-Diaz, Miguel, Kaufman, Brett A., Glineburg, M. Rebecca, Fang, JiKang, Nakagawa, Hiroshi, Basha, Jeelan, Kundu, Tapas, Avadhani, Narayan G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6241121/
https://ncbi.nlm.nih.gov/pubmed/30427907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206897
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