hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction

Telomeres protect against chromosomal damage. Accelerated telomere loss has been associated with premature aging syndromes such as Werner’s syndrome and Dyskeratosis Congenita, while, progressive telomere loss activates a DNA damage response leading to chromosomal instability, typically observed in...

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Detalhes bibliográficos
Publicado no:PLoS One
Principais autores: Guha, Manti, Srinivasan, Satish, Johnson, F. Bradley, Ruthel, Gordon, Guja, Kip, Garcia-Diaz, Miguel, Kaufman, Brett A., Glineburg, M. Rebecca, Fang, JiKang, Nakagawa, Hiroshi, Basha, Jeelan, Kundu, Tapas, Avadhani, Narayan G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6241121/
https://ncbi.nlm.nih.gov/pubmed/30427907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206897
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