Sirtuin 7–mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity

The histone transmethylase complex comprising WD repeat domain 77 (WDR77) and protein arginine methyltransferase 5 (PRMT5) catalyzes dimethylation of H4R3 (H4R3me2) and drives cancer cell proliferation and migration, but its regulation is not fully understood. Here, we report that sirtuin 7 (SIRT7)...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Qi, Hao, Shi, Xiaoyan, Yu, Miao, Liu, Boya, Liu, Minghui, Song, Shi, Chen, Shuaiyi, Zou, Junhua, Zhu, Wei-Guo, Luo, Jianyuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240876/
https://ncbi.nlm.nih.gov/pubmed/30282801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003629
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