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The C-terminal GGAP motif of Hsp70 mediates substrate recognition and stress response in yeast
The allosteric coupling of the highly conserved nucleotide- and substrate-binding domains of Hsp70 has been studied intensively. In contrast, the role of the disordered, highly variable C-terminal region of Hsp70 remains unclear. In many eukaryotic Hsp70s, the extreme C-terminal EEVD motif binds to...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6240856/ https://ncbi.nlm.nih.gov/pubmed/30228181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002691 |
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