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The C-terminal GGAP motif of Hsp70 mediates substrate recognition and stress response in yeast

The allosteric coupling of the highly conserved nucleotide- and substrate-binding domains of Hsp70 has been studied intensively. In contrast, the role of the disordered, highly variable C-terminal region of Hsp70 remains unclear. In many eukaryotic Hsp70s, the extreme C-terminal EEVD motif binds to...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Jones, Gary W., Perrett, Sarah
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240856/
https://ncbi.nlm.nih.gov/pubmed/30228181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002691
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