A patient-derived iPSC model revealed oxidative stress increases facioscapulohumeral muscular dystrophy-causative DUX4

Double homeobox 4 (DUX4), the causative gene of facioscapulohumeral muscular dystrophy (FSHD), is ectopically expressed in the skeletal muscle cells of FSHD patients because of chromatin relaxation at 4q35. The diminished heterochromatic state at 4q35 is caused by either large genome contractions [F...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Hum Mol Genet
Egile Nagusiak: Sasaki-Honda, Mitsuru, Jonouchi, Tatsuya, Arai, Meni, Hotta, Akitsu, Mitsuhashi, Satomi, Nishino, Ichizo, Matsuda, Ryoichi, Sakurai, Hidetoshi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2018
Gaiak:
General Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240734/
https://ncbi.nlm.nih.gov/pubmed/30107443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy293
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak