A Phase II Study of Celecoxib with Irinotecan, 5-Fluorouracil, and Leucovorin in Patients with Previously Untreated Advanced or Metastatic Colorectal Cancer

OBJECTIVE: Colorectal cancer (CRC) is the second leading cause of cancer death in the United States. Cyclooxygenase-2 (COX-2) overexpression is associated with increased tumor invasiveness and proliferation in CRC, and COX-2 inhibition has demonstrated chemopreventive activity. This study investigat...

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Detalhes bibliográficos
Publicado no:Am J Clin Oncol
Main Authors: Chen, Emerson Y., Blanke, Charles D., Haller, Daniel G., Benson, Al B, Dragovich, Tomislav, Lenz, Heinz-Josef, Robles, Carlos, Li, Hong, Mori, Motomi, Mattek, Nora, Sanborn, Rachel E., Lopez, Charles D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240505/
https://ncbi.nlm.nih.gov/pubmed/29782360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/COC.0000000000000465
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