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Monocyte-specific knockout of C/ebpα results in osteopetrosis phenotype, blocks bone loss in ovariectomized mice and reveals an important function of C/ebpα in osteoclast differentiation and function.
CCAAT/enhancer-binding protein α (C/ebpα) is critical for osteoclastogenesis by regulating osteoclast (OC) lineage commitment and is also important for OC differentiation and function in vitro. However, the role of C/ebpα in postnatal skeletal development has not been reported owing to lethality in...
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| Pubblicato in: | J Bone Miner Res |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6240465/ https://ncbi.nlm.nih.gov/pubmed/29149533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3342 |
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