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Monocyte-specific knockout of C/ebpα results in osteopetrosis phenotype, blocks bone loss in ovariectomized mice and reveals an important function of C/ebpα in osteoclast differentiation and function.

CCAAT/enhancer-binding protein α (C/ebpα) is critical for osteoclastogenesis by regulating osteoclast (OC) lineage commitment and is also important for OC differentiation and function in vitro. However, the role of C/ebpα in postnatal skeletal development has not been reported owing to lethality in...

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Detalles Bibliográficos
Publicado en:J Bone Miner Res
Main Authors: Chen, Wei, Zhu, Guochun, Jules, Joel, Nguyen, Diep, Li, Yi-Ping
Formato: Artigo
Idioma:Inglês
Publicado: 2018
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240465/
https://ncbi.nlm.nih.gov/pubmed/29149533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3342
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