Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by loss-of-function mutations in PKD1 or PKD2. Increased glycolysis is a prominent feature of the disease, but how it impacts on other metabolic pathways is unknown. Here, we present an analysis of mouse Pkd1 mutant ce...

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Publicado en:Commun Biol
Main Authors: Podrini, Christine, Rowe, Isaline, Pagliarini, Roberto, Costa, Ana S. H., Chiaravalli, Marco, Di Meo, Ivano, Kim, Hyunho, Distefano, Gianfranco, Tiranti, Valeria, Qian, Feng, di Bernardo, Diego, Frezza, Christian, Boletta, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240072/
https://ncbi.nlm.nih.gov/pubmed/30480096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0200-x
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