Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination

Multiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology in which tissue pathology suggests both immune-dependent attacks to oligodendroglia and primary oligodendrocyte demise. The endocannabinoid system has been crucially involved in the control of autoimmune demyelination and...

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Veröffentlicht in:Biochem Pharmacol
Hauptverfasser: Manterola, Andrea, Bernal-Chico, Ana, Cipriani, Raffaela, Canedo-Antelo, Manuel, Moreno-García, Álvaro, Martín-Fontecha, Mar, Pérez-Cerdá, Fernando, Sánchez-Gómez, María Victoria, Ortega-Gutiérrez, Silvia, Brown, J Mark, Hsu, Ku-Lung, Cravatt, Benjamin, Matute, Carlos, Mato, Susana
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239900/
https://ncbi.nlm.nih.gov/pubmed/30075103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2018.07.042
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