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UNCOVERING THE CONNECTION BETWEEN GENOMIC AND EPIGENOMIC STABILITY DURING AGING WITH EXOGENOUS DNA REPAIR PROTEINS

There is emerging evidence that dysregulation of the epigenome plays a dominant role in organismal decline during aging, but it is uncertain what causes this dysregulation. DNA damage is one possible driver of these epigenetic changes, as induction of DNA damage leads to an accelerated aging of the...

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Detalhes bibliográficos
Publicado no:Innov Aging
Main Authors: Cooney, M, Pichardo, I, Tian, X, Choi, J, Rajman, L, Sinclair, D
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239354/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igy031.3315
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