Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression

TGFβ promotes podocyte hypertrophy and expression of matrix proteins in fibrotic kidney diseases such as diabetic nephropathy. Both mTORC1 and mTORC2 are hyperactive in response to TGFβ in various renal diseases. Deptor is a component of mTOR complexes and a constitutive inhibitor of their activitie...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Das, Falguni, Ghosh-Choudhury, Nandini, Lee, Doug Yoon, Gorin, Yves, Kasinath, Balakuntalam S., Choudhury, Goutam Ghosh
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239304/
https://ncbi.nlm.nih.gov/pubmed/30444896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0207285
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