Oxidative stress creates a unique, CaMKII-mediated substrate for atrial fibrillation in heart failure

The precise mechanisms by which oxidative stress (OS) causes atrial fibrillation (AF) are not known. Since AF frequently originates in the posterior left atrium (PLA), we hypothesized that OS, via calmodulin-dependent protein kinase II (CaMKII) signaling, creates a fertile substrate in the PLA for t...

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Udgivet i:JCI Insight
Main Authors: Yoo, Shin, Aistrup, Gary, Shiferaw, Yohannes, Ng, Jason, Mohler, Peter J., Hund, Thomas J., Waugh, Trent, Browne, Suzanne, Gussak, Georg, Gilani, Mehul, Knight, Bradley P., Passman, Rod, Goldberger, Jeffrey J., Wasserstrom, J. Andrew, Arora, Rishi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238754/
https://ncbi.nlm.nih.gov/pubmed/30385719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.120728
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