Hemoglobin oxidation–dependent reactions promote interactions with band 3 and oxidative changes in sickle cell–derived microparticles

The contribution of intracellular hemoglobin (Hb) oxidation to RBC-derived microparticle (MP) formation is poorly defined in sickle cell disease (SCD). Here we report that sickle Hb (HbS) oxidation, coupled with changes in cytosolic antioxidative proteins, is associated with membrane alterations and...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Jana, Sirsendu, Strader, Michael Brad, Meng, Fantao, Hicks, Wayne, Kassa, Tigist, Tarandovskiy, Ivan, De Paoli, Silvia, Simak, Jan, Heaven, Michael R., Belcher, John D., Vercellotti, Gregory M., Alayash, Abdu I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238743/
https://ncbi.nlm.nih.gov/pubmed/30385713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.120451
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