Hemoglobin oxidation–dependent reactions promote interactions with band 3 and oxidative changes in sickle cell–derived microparticles

The contribution of intracellular hemoglobin (Hb) oxidation to RBC-derived microparticle (MP) formation is poorly defined in sickle cell disease (SCD). Here we report that sickle Hb (HbS) oxidation, coupled with changes in cytosolic antioxidative proteins, is associated with membrane alterations and...

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發表在:JCI Insight
Main Authors: Jana, Sirsendu, Strader, Michael Brad, Meng, Fantao, Hicks, Wayne, Kassa, Tigist, Tarandovskiy, Ivan, De Paoli, Silvia, Simak, Jan, Heaven, Michael R., Belcher, John D., Vercellotti, Gregory M., Alayash, Abdu I.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2018
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238743/
https://ncbi.nlm.nih.gov/pubmed/30385713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.120451
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