Tumor fraction in cell-free DNA as a biomarker in prostate cancer

BACKGROUND. Tumor content in circulating cell-free DNA (cfDNA) is a promising biomarker, but longitudinal dynamics of tumor-derived and non–tumor-derived cfDNA through multiple courses of therapy have not been well described. METHODS. CfDNA from 663 plasma samples from 140 patients with castration-r...

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Vydáno v:JCI Insight
Hlavní autoři: Choudhury, Atish D., Werner, Lillian, Francini, Edoardo, Wei, Xiao X., Ha, Gavin, Freeman, Samuel S., Rhoades, Justin, Reed, Sarah C., Gydush, Gregory, Rotem, Denisse, Lo, Christopher, Taplin, Mary-Ellen, Harshman, Lauren C., Zhang, Zhenwei, O’Connor, Edward P., Stover, Daniel G., Parsons, Heather A., Getz, Gad, Meyerson, Matthew, Love, J. Christopher, Hahn, William C., Adalsteinsson, Viktor A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238737/
https://ncbi.nlm.nih.gov/pubmed/30385733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122109
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