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Barcoding chemical modifications into nucleic acids improves drug stability in vivo
The efficacy of nucleic acid therapies can be limited by unwanted degradation. Chemical modifications are known to improve nucleic acid stability, but the (i) types, (ii) positions, and (iii) numbers of modifications all matter, making chemically optimizing nucleic acids a combinatorial problem. As...
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| Publicado no: | J Mater Chem B |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6238725/ https://ncbi.nlm.nih.gov/pubmed/30555697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8tb01642a |
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