Barcoding chemical modifications into nucleic acids improves drug stability in vivo

The efficacy of nucleic acid therapies can be limited by unwanted degradation. Chemical modifications are known to improve nucleic acid stability, but the (i) types, (ii) positions, and (iii) numbers of modifications all matter, making chemically optimizing nucleic acids a combinatorial problem. As...

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Bibliografiske detaljer
Udgivet i:J Mater Chem B
Main Authors: Sago, Cory D., Kalathoor, Sujay, Fitzgerald, Jordan P., Lando, Gwyneth N., Djeddar, Naima, Bryksin, Anton V., Dahlman, James E.
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2018
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238725/
https://ncbi.nlm.nih.gov/pubmed/30555697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8tb01642a
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