Barcoding chemical modifications into nucleic acids improves drug stability in vivo

The efficacy of nucleic acid therapies can be limited by unwanted degradation. Chemical modifications are known to improve nucleic acid stability, but the (i) types, (ii) positions, and (iii) numbers of modifications all matter, making chemically optimizing nucleic acids a combinatorial problem. As...

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Bibliographic Details
Published in:J Mater Chem B
Main Authors: Sago, Cory D., Kalathoor, Sujay, Fitzgerald, Jordan P., Lando, Gwyneth N., Djeddar, Naima, Bryksin, Anton V., Dahlman, James E.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2018
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238725/
https://ncbi.nlm.nih.gov/pubmed/30555697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8tb01642a
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