Metformin causes cancer cell death through downregulation of p53-dependent differentiated embryo chondrocyte 1

BACKGROUND: Metformin is the most commonly used first-line medicine for type II diabetes mellitus. Acting via AMP-activated protein kinase, it has been used for more than 60 years and has an outstanding safety record. Metformin also offers protection against cancer, but its precise mechanisms remain...

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Veröffentlicht in:J Biomed Sci
Hauptverfasser: Hsieh Li, Shu-Man, Liu, Shu-Ting, Chang, Yung-Lung, Ho, Ching-Liang, Huang, Shih-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238313/
https://ncbi.nlm.nih.gov/pubmed/30442142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-018-0478-5
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