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Characterization of a new mouse p53 variant: loss-of-function and gain-of-function

BACKGROUND: p53 is a major tumor suppressor that is inactivated in over 50% of human cancer types through either mutation or inactivating interactions with viral or cellular proteins. The uncertainties around the link between p53 status, therapeutic response, and outcome in cancer suggest that addit...

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Autors principals: Chan, James Yi-Hsin, Chen, Ying-Chuan, Liu, Shu-Ting, Chou, Wei-Yuan, Ho, Ching-Liang, Huang, Shih-Ming
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022406/
https://ncbi.nlm.nih.gov/pubmed/24884657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-21-40
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