AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation

AMP-activated protein kinase (AMPK) α1 is activated in platelets on thrombin or collagen stimulation, and as a consequence, phosphorylates and inhibits acetyl-CoA carboxylase (ACC). Because ACC is crucial for the synthesis of fatty acids, which are essential for platelet activation, we hypothesized...

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Udgivet i:Blood
Main Authors: Lepropre, Sophie, Kautbally, Shakeel, Octave, Marie, Ginion, Audrey, Onselaer, Marie-Blanche, Steinberg, Gregory R., Kemp, Bruce E., Hego, Alexandre, Wéra, Odile, Brouns, Sanne, Swieringa, Frauke, Giera, Martin, Darley-Usmar, Victor M., Ambroise, Jérôme, Guigas, Bruno, Heemskerk, Johan, Bertrand, Luc, Oury, Cécile, Beauloye, Christophe, Horman, Sandrine
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2018
Fag:
Platelets and Thrombopoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238154/
https://ncbi.nlm.nih.gov/pubmed/30018077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-02-831503
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