Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture

Aortic intramural hematoma (IMH) can evolve toward reabsorption, dissection or aneurysm. Hypertension is the most common predisposing factor in IMH and aneurysm patients, and the hypertensive mediator angiotensin-II induces both in mice. We have previously shown that constitutive deletion of Rcan1 i...

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Опубликовано в: :Nat Commun
Главные авторы: Villahoz, Silvia, Yunes-Leites, Paula Sofía, Méndez-Barbero, Nerea, Urso, Katia, Bonzon-Kulichenko, Elena, Ortega, Sagrario, Nistal, J. Francisco, Vazquez, Jesus, Offermanns, Stefan, Redondo, Juan Miguel, Campanero, Miguel R.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237779/
https://ncbi.nlm.nih.gov/pubmed/30442942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07071-7
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