Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture

Aortic intramural hematoma (IMH) can evolve toward reabsorption, dissection or aneurysm. Hypertension is the most common predisposing factor in IMH and aneurysm patients, and the hypertensive mediator angiotensin-II induces both in mice. We have previously shown that constitutive deletion of Rcan1 i...

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Vydáno v:Nat Commun
Hlavní autoři: Villahoz, Silvia, Yunes-Leites, Paula Sofía, Méndez-Barbero, Nerea, Urso, Katia, Bonzon-Kulichenko, Elena, Ortega, Sagrario, Nistal, J. Francisco, Vazquez, Jesus, Offermanns, Stefan, Redondo, Juan Miguel, Campanero, Miguel R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237779/
https://ncbi.nlm.nih.gov/pubmed/30442942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07071-7
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