C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast‐inducing chemokine CXCL10

The anaphylatoxin C5a is generated upon activation of the complement system, a crucial arm of innate immunity. C5a mediates proinflammatory actions via the C5a receptor C5aR1 and thereby promotes host defence, but also modulates tissue homeostasis. There is evidence that the C5a/C5aR1 axis is critic...

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Détails bibliographiques
Publié dans:J Cell Mol Med
Auteurs principaux: Mödinger, Yvonne, Rapp, Anna, Pazmandi, Julia, Vikman, Anna, Holzmann, Karlheinz, Haffner‐Luntzer, Melanie, Huber‐Lang, Markus, Ignatius, Anita
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237570/
https://ncbi.nlm.nih.gov/pubmed/30247799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13873
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