Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS

Neuroinflammation is a recognized pathogenic mechanism underlying motor neuron degeneration in amyotrophic lateral sclerosis (ALS), but the inflammatory mechanisms influencing peripheral motor axon degeneration remain largely unknown. A recent report showed a pathogenic role for c-Kit–expressing mas...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Trias, Emiliano, King, Peter H., Si, Ying, Kwon, Yuri, Varela, Valentina, Ibarburu, Sofía, Kovacs, Mariángeles, Moura, Ivan C., Beckman, Joseph S., Hermine, Olivier, Barbeito, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237484/
https://ncbi.nlm.nih.gov/pubmed/30282815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.123249
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