Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice

Copeptin, a marker of arginine vasopressin (AVP) secretion, is elevated throughout human pregnancies complicated by preeclampsia (PE), and AVP infusion throughout gestation is sufficient to induce the major phenotypes of PE in mice. Thus, we hypothesized a role for AVP in the pathogenesis of PE. AVP...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Sandgren, Jeremy A., Deng, Guorui, Linggonegoro, Danny W., Scroggins, Sabrina M., Perschbacher, Katherine J., Nair, Anand R., Nishimura, Taryn E., Zhang, Shao Yang, Agbor, Larry N., Wu, Jing, Keen, Henry L., Naber, Meghan C., Pearson, Nicole A., Zimmerman, Kathy A., Weiss, Robert M., Bowdler, Noelle C., Usachev, Yuriy M., Santillan, Donna A., Potthoff, Matthew J., Pierce, Gary L., Gibson-Corley, Katherine N., Sigmund, Curt D., Santillan, Mark K., Grobe, Justin L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237463/
https://ncbi.nlm.nih.gov/pubmed/30282823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.99403
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