Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies

The identification of targetable vulnerabilities in the context of therapeutic resistance is a key challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic feature of chronic lymphocytic leukemia (CLL), irrespective of splicing factor mutation status, which was asso...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Hacken, Elisa ten, Valentin, Rebecca, Regis, Fara Faye D., Sun, Jing, Yin, Shanye, Werner, Lillian, Deng, Jing, Gruber, Michaela, Wong, Jessica, Zheng, Mei, Gill, Amy L., Seiler, Michael, Smith, Peter, Thomas, Michael, Buonamici, Silvia, Ghia, Emanuela M., Kim, Ekaterina, Rassenti, Laura Z., Burger, Jan A., Kipps, Thomas J., Meyerson, Matthew L., Bachireddy, Pavan, Wang, Lili, Reed, Robin, Neuberg, Donna, Carrasco, Ruben D., Brooks, Angela N., Letai, Anthony, Davids, Matthew S., Wu, Catherine J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237462/
https://ncbi.nlm.nih.gov/pubmed/30282833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121438
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