Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies

The identification of targetable vulnerabilities in the context of therapeutic resistance is a key challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic feature of chronic lymphocytic leukemia (CLL), irrespective of splicing factor mutation status, which was asso...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Hacken, Elisa ten, Valentin, Rebecca, Regis, Fara Faye D., Sun, Jing, Yin, Shanye, Werner, Lillian, Deng, Jing, Gruber, Michaela, Wong, Jessica, Zheng, Mei, Gill, Amy L., Seiler, Michael, Smith, Peter, Thomas, Michael, Buonamici, Silvia, Ghia, Emanuela M., Kim, Ekaterina, Rassenti, Laura Z., Burger, Jan A., Kipps, Thomas J., Meyerson, Matthew L., Bachireddy, Pavan, Wang, Lili, Reed, Robin, Neuberg, Donna, Carrasco, Ruben D., Brooks, Angela N., Letai, Anthony, Davids, Matthew S., Wu, Catherine J.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237462/
https://ncbi.nlm.nih.gov/pubmed/30282833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121438
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