α(v)β(3) Integrin drives fibroblast contraction and strain stiffening of soft provisional matrix during progressive fibrosis

Fibrosis is characterized by persistent deposition of extracellular matrix (ECM) by fibroblasts. Fibroblast mechanosensing of a stiffened ECM is hypothesized to drive the fibrotic program; however, the spatial distribution of ECM mechanics and their derangements in progressive fibrosis are poorly ch...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Fiore, Vincent F., Wong, Simon S., Tran, Coleen, Tan, Chunting, Xu, Wenwei, Sulchek, Todd, White, Eric S., Hagood, James S., Barker, Thomas H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237458/
https://ncbi.nlm.nih.gov/pubmed/30333317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97597
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