Brugada syndrome trafficking–defective Nav1.5 channels can trap cardiac Kir2.1/2.2 channels

Cardiac Nav1.5 and Kir2.1–2.3 channels generate Na (I(Na)) and inward rectifier K (I(K1)) currents, respectively. The functional I(Na) and I(K1) interplay is reinforced by the positive and reciprocal modulation between Nav15 and Kir2.1/2.2 channels to strengthen the control of ventricular excitabili...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Pérez-Hernández, Marta, Matamoros, Marcos, Alfayate, Silvia, Nieto-Marín, Paloma, Utrilla, Raquel G., Tinaquero, David, de Andrés, Raquel, Crespo, Teresa, Ponce-Balbuena, Daniela, Willis, B. Cicero, Jiménez-Vazquez, Eric N., Guerrero-Serna, Guadalupe, da Rocha, Andre M., Campbell, Katherine, Herron, Todd J., Díez-Guerra, F. Javier, Tamargo, Juan, Jalife, José, Caballero, Ricardo, Delpón, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237221/
https://ncbi.nlm.nih.gov/pubmed/30232268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96291
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