Synonymous mutation adenomatous polyposis coli(Δ486s) affects exon splicing and may predispose patients to adenomatous polyposis coli/mutY DNA glycosylase mutation-negative familial adenomatous polyposis

Familial adenomatous polyposis (FAP) is an autosomal dominant-inherited colorectal cancer. Recent advances in genetics have indicated that the majority of patients with FAP carry germline mutations of the adenomatous polyposis coli (APC) and mutY DNA glycosylase (MUTYH) genes. However, a large subse...

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Detalhes bibliográficos
Publicado no:Mol Med Rep
Main Authors: Liu, Wei Qing, Dong, Jian, Peng, Yan Xia, Li, Wen Liang, Yang, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236305/
https://ncbi.nlm.nih.gov/pubmed/30272267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2018.9495
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