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Neuronal and glial factors contributing to sex differences in opioid modulation of pain

Morphine remains one of the most widely prescribed opioids for alleviation of persistent and/or severe pain; however, multiple preclinical and clinical studies report that morphine is less efficacious in females compared to males. Morphine primarily binds to the mu opioid receptor, a prototypical G-...

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Publicat a:Neuropsychopharmacology
Autors principals: Averitt, Dayna L., Eidson, Lori N., Doyle, Hillary H., Murphy, Anne Z.
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235988/
https://ncbi.nlm.nih.gov/pubmed/29973654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0127-4
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