Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD(+)

Cell models of mitochondrial complex I (CI) deficiency display activation of glycolysis to compensate for the loss in mitochondrial ATP production. This adaptation can mask other relevant deficiency-induced aberrations in cell physiology. Here we investigated the viability, mitochondrial morphofunct...

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Udgivet i:Cell Death Dis
Main Authors: Iannetti, Eligio F., Smeitink, Jan A. M., Willems, Peter H. G. M., Beyrath, Julien, Koopman, Werner J. H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235972/
https://ncbi.nlm.nih.gov/pubmed/30429455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1179-4
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