Stem cell-secreted 14,15- epoxyeicosatrienoic acid rescues cholesterol homeostasis and autophagic flux in Niemann–Pick-type C disease

We previously demonstrated that the direct transplantation of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) into the dentate gyrus ameliorated the neurological symptoms of Niemann–Pick type C1 (NPC1)-mutant mice. However, the clinical presentation of NPC1-mutant mice was not...

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Udgivet i:Exp Mol Med
Main Authors: Kang, Insung, Lee, Byung-Chul, Lee, Jin Young, Kim, Jae-Jun, Sung, Eun-Ah, Lee, Seung Eun, Shin, Nari, Choi, Soon Won, Seo, Yoojin, Kim, Hyung-Sik, Kang, Kyung-Sun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235958/
https://ncbi.nlm.nih.gov/pubmed/30429460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-018-0176-0
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