A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Familial hypercholesterolemia (FH) is mostly caused by low-density lipoprotein receptor (LDLR) mutations and results in an increased risk of early-onset cardiovascular disease due to marked elevation of LDL cholesterol (LDL-C) in blood. Statins are the first line of lipid-lowering drugs for treating...

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Detalhes bibliográficos
Publicado no:J Vis Exp
Main Authors: Yang, Jiayin, Wong, Lai-Yung, Tian, Xiao-Yu, Wei, Rui, Lai, Wing-Hon, Au, Ka-Wing, Luo, Zhiwei, Ward, Carl, Ho, Wai-In, Ibañez, David P., Liu, Hao, Bao, Xichen, Qin, Baoming, Huang, Yu, Esteban, Miguel A., Tse, Hung-Fat
Formato: Artigo
Idioma:Inglês
Publicado em: MyJove Corporation 2018
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235199/
https://ncbi.nlm.nih.gov/pubmed/30272645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/57556
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