Downregulation of CLDN7 due to promoter hypermethylation is associated with human clear cell renal cell carcinoma progression and poor prognosis

BACKGROUND: Metastasis is the primary cause of death in renal cell carcinoma (RCC). Loss of cell-to-cell adhesion, including tight junctions (TJs) is the initial step in the process of metastasis. Claudin-7 (CLDN7) is a major component of TJs. However, the clinical significance and its regulation of...

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Dettagli Bibliografici
Pubblicato in:J Exp Clin Cancer Res
Autori principali: Li, Yifan, Gong, Yanqing, Ning, Xianghui, Peng, Ding, Liu, Libo, He, Shiming, Gong, Kan, Zhang, Cuijian, Li, Xuesong, Zhou, Liqun
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234584/
https://ncbi.nlm.nih.gov/pubmed/30428910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0924-y
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