Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo

Dyslipidemia is a risk factor for clinically significant thrombotic events. In this condition, scavenger receptor CD36 potentiates platelet reactivity through recognition of circulating oxidized lipids. CD36 promotes thrombosis by activating redox-sensitive signaling molecules, such as the MAPK extr...

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Dades bibliogràfiques
Publicat a:Blood Adv
Autors principals: Yang, Moua, Kholmukhamedov, Andaleb, Schulte, Marie L., Cooley, Brian C., Scoggins, Na’il O., Wood, Jeremy P., Cameron, Scott J., Morrell, Craig N., Jobe, Shawn M., Silverstein, Roy L.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2018
Matèries:
Thrombosis and Hemostasis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234364/
https://ncbi.nlm.nih.gov/pubmed/30381401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018025411
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