Recombinant factor VIII Fc fusion protein drives regulatory macrophage polarization

The main complication of replacement therapy with factor in hemophilia A (HemA) is the formation of inhibitors (neutralizing anti–factor VIII [FVIII] antibodies) in ∼30% of severe HemA patients. Because these inhibitors render replacement FVIII treatment essentially ineffective, preventing or elimin...

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Udgivet i:Blood Adv
Main Authors: Kis-Toth, Katalin, Rajani, Gaurav Manohar, Simpson, Allison, Henry, Kate L., Dumont, Jennifer, Peters, Robert T., Salas, Joe, Loh, Christine
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2018
Fag:
Immunobiology and Immunotherapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234359/
https://ncbi.nlm.nih.gov/pubmed/30396910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018024497
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