EGFR gene copy number by FISH may predict outcome of necitumumab in squamous lung carcinomas: analysis from the SQUIRE study.

INTRODUCTION: Necitumumab is a monoclonal antibody targeting the epidermal growth factor receptor (EGFR). In the SQUIRE trial, the addition of necitumumab to chemotherapy in squamous cell lung cancer (SCC) significantly improved overall survival (OS) (HR=0.84); in a post-hoc analysis, EGFR copy numb...

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Publicado no:J Thorac Oncol
Main Authors: Genova, Carlo, Socinski, Mark A., Hozak, Rebecca R., Mi, Gu, Kurek, Raffael, Shahidi, Javad, Paz-Ares, Luis, Thatcher, Nick, Rivard, Christopher J., Varella- Garcia, Marileila, Hirsch, Fred R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233716/
https://ncbi.nlm.nih.gov/pubmed/29158193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2017.11.109
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