Blockade of Rostral Ventrolateral Medulla Apelin Receptors Does Not Attenuate Arterial Pressure in SHR and (L)-NAME-Induced Hypertensive Rats

Dysfunction of the apelinergic system, comprised of the neuropeptide apelin mediating its effects via the G protein-coupled apelin receptor (APJ), may underlie the onset of cardiovascular disease such as hypertension. Apelin expression is increased in the rostral ventrolateral medulla (RVLM) in spon...

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發表在:Front Physiol
Main Authors: Griffiths, Philip R., Lolait, Stephen J., Pearce, Louise E., McBryde, Fiona D., Paton, Julian F. R., O’Carroll, Anne-Marie
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2018
主題:
Physiology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232890/
https://ncbi.nlm.nih.gov/pubmed/30459635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01488
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