Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration

Hypoxia, which characterizes most tumor tissues, can alter the function of different immune cell types, favoring tumor escape mechanisms. In this study, we show that hypoxia profoundly acts on NK cells by influencing their transcriptome, affecting their immunoregulatory functions, and changing the c...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Parodi, Monica, Raggi, Federica, Cangelosi, Davide, Manzini, Claudia, Balsamo, Mirna, Blengio, Fabiola, Eva, Alessandra, Varesio, Luigi, Pietra, Gabriella, Moretta, Lorenzo, Mingari, Maria Cristina, Vitale, Massimo, Bosco, Maria Carla
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232835/
https://ncbi.nlm.nih.gov/pubmed/30459756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02358
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