Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration

Hypoxia, which characterizes most tumor tissues, can alter the function of different immune cell types, favoring tumor escape mechanisms. In this study, we show that hypoxia profoundly acts on NK cells by influencing their transcriptome, affecting their immunoregulatory functions, and changing the c...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Parodi, Monica, Raggi, Federica, Cangelosi, Davide, Manzini, Claudia, Balsamo, Mirna, Blengio, Fabiola, Eva, Alessandra, Varesio, Luigi, Pietra, Gabriella, Moretta, Lorenzo, Mingari, Maria Cristina, Vitale, Massimo, Bosco, Maria Carla
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232835/
https://ncbi.nlm.nih.gov/pubmed/30459756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02358
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