Cerium Oxide Nanoparticles Re-establish Cell Integrity Checkpoints and Apoptosis Competence in Irradiated HaCat Cells via Novel Redox-Independent Activity

Cerium oxide nanoparticles (CNPs) are potent radical scavengers protecting cells from oxidative insults, including ionizing radiation. Here we show that CNPs prevent X-ray-induced oxidative imbalance reducing DNA breaks on HaCat keratinocytes, nearly abating mutagenesis. At the same time, and in spi...

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Publicat a:Front Pharmacol
Autors principals: Caputo, Fanny, Giovanetti, Anna, Corsi, Francesca, Maresca, Vittoria, Briganti, Stefania, Licoccia, Silvia, Traversa, Enrico, Ghibelli, Lina
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232693/
https://ncbi.nlm.nih.gov/pubmed/30459604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01183
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