Cerium Oxide Nanoparticles Re-establish Cell Integrity Checkpoints and Apoptosis Competence in Irradiated HaCat Cells via Novel Redox-Independent Activity

Cerium oxide nanoparticles (CNPs) are potent radical scavengers protecting cells from oxidative insults, including ionizing radiation. Here we show that CNPs prevent X-ray-induced oxidative imbalance reducing DNA breaks on HaCat keratinocytes, nearly abating mutagenesis. At the same time, and in spi...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Autores principales: Caputo, Fanny, Giovanetti, Anna, Corsi, Francesca, Maresca, Vittoria, Briganti, Stefania, Licoccia, Silvia, Traversa, Enrico, Ghibelli, Lina
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232693/
https://ncbi.nlm.nih.gov/pubmed/30459604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01183
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