Recombinant Infectious Bronchitis Viruses Expressing Chimeric Spike Glycoproteins Induce Partial Protective Immunity against Homologous Challenge despite Limited Replication In Vivo

Vaccination regimes against Infectious bronchitis virus (IBV), which are based on a single virus serotype, often induce insufficient levels of cross-protection against serotypes and two or more antigenically diverse vaccines are used in attempt to provide broader protection. Amino acid differences i...

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Bibliographic Details
Published in:J Virol
Main Authors: Ellis, Samantha, Keep, Sarah, Britton, Paul, de Wit, Sjaak, Bickerton, Erica, Vervelde, Lonneke
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232476/
https://ncbi.nlm.nih.gov/pubmed/30209177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01473-18
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