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Potent Neutralizing Human Monoclonal Antibodies Preferentially Target Mature Dengue Virus Particles: Implication for Novel Strategy for Dengue Vaccine

The four serotypes of dengue virus (DENV) cause the most important mosquito-borne viral disease in humans. The envelope (E) protein is the major target of neutralizing antibodies and contains 3 domains (domain I [DI], DII, and DIII). Recent studies reported that human monoclonal antibodies (MAbs) re...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Tsai, Wen-Yang, Chen, Hui-Ling, Tsai, Jih-Jin, Dejnirattisai, Wanwisa, Jumnainsong, Amonrat, Mongkolsapaya, Juthathip, Screaton, Gavin, Crowe, James E., Wang, Wei-Kung
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232466/
https://ncbi.nlm.nih.gov/pubmed/30185598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00556-18
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