Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus 2 Release from Cells

Herpes simplex virus 2 (HSV-2) can productively infect many different cell types of human and nonhuman origin. Here we demonstrate interconnected roles for two host enzymes, heparanase (HPSE) and cathepsin L, in HSV-2 release from cells. In vaginal epithelial cells, HSV-2 causes heparan sulfate shed...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Hopkins, James, Yadavalli, Tejabhiram, Agelidis, Alex M., Shukla, Deepak
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232460/
https://ncbi.nlm.nih.gov/pubmed/30232188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01179-18
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