Metformin Modulates High Glucose-Incubated Human Umbilical Vein Endothelial Cells Proliferation and Apoptosis Through AMPK/CREB/BDNF Pathway

Cardiovascular disease (CVD) is a leading cause of mortality and morbidity among patients with diabetes. Endothelial dysfunction is an early physiological event in CVD. Metformin, a common oral antihyperglycemic agent, has been demonstrated to directly affect endothelial cell function. Brain-derived...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Han, Xiqiong, Wang, Bilei, Sun, Yuning, Huang, Jia, Wang, Xin, Ma, Wenqi, Zhu, Yi, Xu, Rongfeng, Jin, Hong, Liu, Naifeng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232387/
https://ncbi.nlm.nih.gov/pubmed/30459620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01266
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