Anti-angiogenic Effects of Metformin, an AMPK Activator, on Human Umbilical Vein Endothelial Cells and on Granulation Tissue in Rat

OBJECTIVE(S): Metformin is well known for activation of AMP-activated protein kinase (AMPK). AMPK activation inhibits mammalian target of rapamycin (mTOR) as a key signaling process in cell proliferation. Recent epidemiological studies demonstrate that metformin lowers the risk for several types of...

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Main Authors: Soraya, Hamid, Esfahanian, Nilufar, Shakiba, Yadollah, Ghazi-Khansari, Mahmood, Nikbin, Behroz, Hafezzadeh, Hasan, Maleki Dizaji, Nasrin, Garjani, Alireza
Formato: Artigo
Idioma:Inglês
Publicado em: Mashhad University of Medical Sciences 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646233/
https://ncbi.nlm.nih.gov/pubmed/23653852
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