Effect of the BH3 Mimetic Polyphenol (–)-Gossypol (AT-101) on the in vitro and in vivo Growth of Malignant Mesothelioma

Malignant mesothelioma (MM) is a primary tumor arising from mesothelial cells. The survival of MM patients following traditional chemotherapy is poor, thus innovative treatments for MM are needed. (-)-gossypol (AT-101) is a BH3 mimetic compound which possesses anti-tumoral activity by targeting mult...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Benvenuto, Monica, Mattera, Rosanna, Sticca, Joshua Ismaele, Rossi, Piero, Cipriani, Chiara, Giganti, Maria Gabriella, Volpi, Antonio, Modesti, Andrea, Masuelli, Laura, Bei, Roberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232343/
https://ncbi.nlm.nih.gov/pubmed/30459622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01269
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